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  • GILEAD and the GILEAD logo are trademarks of Gilead Sciences, Inc. KITE and the KITE logo are trademarks of Kite Pharma, Inc. © 2023 Gilead Sciences, Inc. All rights reserved. US-UNBP-2480 12/23

Lung and thoracic research.

Lung cancer is the second most common cancer with 2.2M annual new lung cancer diagnoses globally¹, and is the leading cause of cancer death with 1.8M annual deaths². Up to 85% of lung cancers are NSCLC and 10-15% are SCLC. NSCLC tends to grow and spread slower than SCLC, but is still an aggressive disease with poor prognosis, with major unmet need for patients.

Research commitment
Clinical trials in progress
Scientific focus

Committed to patients living with lung and thoracic cancer

Select a trial below to view additional details (trial brochure or clinicaltrials.gov)
Timeline is based on trial start dates.
The safety and efficacy of these investigational agents and/or uses have not been established. There is no guarantee that they will become commercially available.

2019
TROPiCS-03

2L+ mNSCLC, mHNSCC, mSCLC cohorts

2020
ARC-7d

1L mNSCLC

2021
ARC-10d

1L mNSCLC, PD-L1+, TPS≥50%

 
ELEVATE HNSCC

1-3L mHNSCC

 
ELEVATE Lung/UC

2L+ mNSCLC, mSCLC

 
EVOKE-01*

2-3L mNSCLC

2022
PACIFIC-8c

Stage 3 NSCLC

 
EVOKE-02a*

1L mNSCLC

 
STAR-121d

1L mNSCLC

2023
EDGE-Lungd

1-2L mNSCLC

 
EVOKE-03a,b

1L mNSCLC, PD-L1+, TPS≥50%

 
VELOCITY-Lungd

1-2L mNSCLC

00

Clinical trials in progress

Lung and thoracic clinical trials actively recruiting.

Rollover trial for links to trial brochures and/or clinicaltrials.gov records.

The safety and efficacy of these investigational agents and/or uses have not been established. There is no guarantee that they will become commercially available.

1L mNSCLC, PD-L1+, TPS≥50%
Phase 3 randomized, open-label, multicenter, comparator-controlled clinical study of pembrolizumab in combination with sacituzumab govitecan versus pembrolizumab monotherapy as first-line treatment in patients with PD-L1 TPS ≥50% mNSCLC
NSCLC

EVOKE-03a,b

Stage 3 NSCLC
Phase 3 randomized, double-blind, placebo-controlled, multicentre, international study of durvalumab plus domvanalimab in participants with locally advanced (Stage III), unresectable NSCLC whose disease has not progressed following definitive platinum-based cCRT
NSCLC

PACIFIC-8c

1L mNSCLC, PD-L1+, TPS≥50%
Phase 3 study to evaluate zimberelimab combined with domvanalimab compared to pembrolizumab in front-line, PD-L1-high, locally advanced or metastatic NSCLC
NSCLC

ARC-10d

1L mNSCLC
Phase 3 randomized, open-label study to evaluate zimberelimab and domvanalimab in combination with chemotherapy versus pembrolizumab with chemotherapy for the 1L treatment of patients with metastatic NSCLC with no EGFR or ALK genomic tumor aberrations
NSCLC

STAR-121d

1-2L mNSCLC
Phase 2, open-label, platform study, to evaluate immunotherapy-based combinations in participants with advanced NSCLC
NSCLC

EDGE-Lungd

1-2L mNSCLC
Phase 2 platform study evaluating the safety and efficacy of novel treatment combinations in patients with lung cancer
NSCLC

VELOCITY-Lungd

1-3L mHNSCC
Phase 2 open-label study of magrolimab combination therapy in patients with metastatic or unresectable, locally recurrent HNSCC
HNSCC

ELEVATE HNSCC

Scientific focus

The safety and efficacy of these investigational agents and/or uses have not been established. There is no guarantee that they will become commercially available.
MoAs in research
sacituzumab govitecan-hziy
dom and zim
etruma and quemli


Swipe left to view our late-stage asset mechanism of action video(s) that our trials are investigating in Lung and Thoracic Cancer treatment.

Clinicaltrials.gov may not reflect the most up-to-date information on the trials shown.

*Trial status: active, not recruiting.
aIn collaboration with Merck. bEVOKE-03 is being operationalized by Merck. cIn collaboration with Arcus Biosciences and AstraZeneca. AstraZeneca is the study sponsor. dIn collaboration with Arcus Biosciences.

cCRT, concurrent chemoradiation therapy; CD, cluster of differentiation; EGFR, epidermal growth factor receptor; FL, follicular lymphoma; HNSCC, head and neck squamous cell carcinoma; mNSCLC, metastatic non-small cell lung cancer; mSCLC, metastatic small cell lung cancer; mTNBC, metastatic triple-negative breast cancer; mUC, metastatic urothelial cancer; NCT, national clinical trial; NSCLC, non-small cell lung cancer; PD-L1, programd death-ligand 1; R/R, relapsed/refractory; SCLC, small cell lung cancer;TPS, tumor proportion score.

1. Sung H et al. CA Cancer J Clin. 2021;71:209-249. 2. NCI SEER Cancer Stat Facts: Lung and Bronchus Cancer. Accessed May 30, 2023. https://seer.cancer.gov/statfacts/html/lungb.html